I've spent some of my evenings lately to build accessible alternative interfaces to successful social networks and "Web 2.0" sites. I've taken on feedback from disabled users and agencies that work with people with varying disabilities. The first was an easier interface to YouTube and now I tackled Flickr and cut it down to the bear necessities.
As several people asked how I did the Flickr interface, I wrote up some step-by-step instructions, analyzing the issues and then taking the API to work around them.
This is one example where providing a good API can empower developers to remove barriers you might not be aware of for you. I hope to be able to show you more of those in the future - if there is interest.
The code examples are available and are licensed with BSD, so feel free to re-use them.
Yahoo Developer Network